Copper (II) coordination to amyloid β: murine versus human peptide

Copper (II) coordination to amyloid β: murine versus human peptide

H Eury, C Bijani, P Faller… - Angewandte Chemie …, 2011 - Wiley Online Library

Be wary of mice: At physiological pH values, CuII binding to the human and murine amyloid
β peptides differs significantly. The key mutation R5G in the murine CuII species results in
coordination of the amidyl nitrogen atom of the Gly5 His6 bond (see scheme). The higher …

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