[HTML] A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival

[HTML] A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival

NA Cohen, ML Stewart, E Gavathiotis, JL Tepper… - Chemistry & biology, 2012 - Elsevier

Cancer cells hijack BCL-2 family survival proteins to suppress the death effectors and
thereby enforce an immortal state. This is accomplished biochemically by an antiapoptotic
surface groove that neutralizes the proapoptotic BH3 α helix of death proteins. Antiapoptotic …

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