Total synthesis of the large non-ribosomal peptide polytheonamide B

Total synthesis of the large non-ribosomal peptide polytheonamide B

M Inoue, N Shinohara, S Tanabe, T Takahashi… - Nature Chemistry, 2010 - nature.com

Polytheonamide B is by far the largest non-ribosomal peptide known at present, and
displays extraordinary cytotoxicity (EC 50= 68 pg ml− 1, mouse leukaemia P388 cells). Its 48
amino-acid residues include a variety of non-proteinogenic d-and l-amino acids, and the …

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