2017年12月30日星期六

[HTML] Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide

[HTML] Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide

J Hwang, BH San, NJ Turner, LJ White, DM Faulk… - Acta biomaterialia, 2017 - Elsevier
Abstract Decellularized extracellular matrix (ECM) derived from tissues and organs are
emerging as important scaffold materials for regenerative medicine. Many believe that
preservation of the native ECM structure during decellularization is highly desirable.


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptide-photosensitizer conjugate

Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptide-photosensitizer conjugate

G Shim, MG Kim, H Jin, J Kim, YK Oh - Acta Pharmacologica Sinica, 2017 - nature.com
Abstract In this study we designed a claudin 4-directed dual photodynamic and
photothermal system, in which a 30-amino acid claudin 4-binding peptide, Clostridium
perfringens enterotoxin (CPE), was linked to a photodynamic agent chlorin e6 (Ce6) through


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Urea-containing peptide boronic acids as potent proteasome inhibitors

Urea-containing peptide boronic acids as potent proteasome inhibitors

LQ Han, X Yuan, XY Wu, RD Li, B Xu, Q Cheng… - European journal of …, 2017 - Elsevier
Abstract A novel class of urea-containing peptide boronic acids as proteasome inhibitors
was designed by introducing a urea scaffold to replace an amido bond. Compounds were
synthesized and their antitumor activities were evaluated. After two rounds of optimizations,


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Cutting Edge: LL-37–Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers

Cutting Edge: LL-37–Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers

SH Kim, YN Kim, YS Jang - The Journal of Immunology, 2017 - Am Assoc Immnol
Abstract Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal
centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously
induced by the gut microbiota, and their maintenance contributes to the induction of strong


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Vaccination with recombinant RgpA peptide protects against Porphyromonas gingivalis‐induced bone loss

Vaccination with recombinant RgpA peptide protects against Porphyromonas gingivalis‐induced bone loss

A Wilensky, J Potempa… - Journal of periodontal …, 2017 - Wiley Online Library
Immunization with native RgpA shifted the immune response toward an anti-inflammatory response
as demonstrated by decreased proinflammatory cytokine IL-1β production and greater anti-inflammatory
cytokine IL-4 in chamber exudates. Systemically, immunization with recombinant RgpA peptide


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

EK Sully, BL Geller, L Li, CM Moody… - Journal of …, 2017 - academic.oup.com
Objectives: The objective of this study was to test the efficacy of an inhibitor of the New Delhi
metallo-β-lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene
has the potential to restore antibiotic susceptibility in all bacteria carrying the gene. Methods:


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Pleiotropic Role of Recombinant Silaffin‐Like Cationic Polypeptide P5S3: Peptide‐Induced Silicic Acid Stabilization, Silica Formation and Inhibition of Silica …

Pleiotropic Role of Recombinant Silaffin‐Like Cationic Polypeptide P5S3: Peptide‐Induced Silicic Acid Stabilization, Silica Formation and Inhibition of Silica …

A Spinthaki, C Zerfaß, H Paulsen, S Hobe… - …, 2017 - Wiley Online Library
Abstract Silica-mineralizing organisms such as diatoms manage several aspects of silica
chemistry when polymerizing monomeric silicic acid into amorphous silica. Silicic acid is
undersaturated in the diatoms' habitats and mechanisms of enrichment and prevention of


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Alzheimer's disease: Development of a sensitive label-free electrochemical immunosensor for detection of amyloid beta peptide

Alzheimer's disease: Development of a sensitive label-free electrochemical immunosensor for detection of amyloid beta peptide

P Carneiro, J Loureiro, C Delerue-Matos… - Sensors and Actuators B …, 2017 - Elsevier
Abstract In this work, a highly sensitive label-free immunosensor for detection of the main
biomarker of Alzheimer's disease (AD), amyloid beta 1–42 (Aβ (1–42)), is presented. A gold
electrode was modified with a mercaptopropionic acid (MPA) self-assembled monolayer,


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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[HTML] Hypoxia exposure and B‐type natriuretic peptide release from Langendorff heart of rats

[HTML] Hypoxia exposure and B‐type natriuretic peptide release from Langendorff heart of rats

K Anttila, T Streng, J Pispa, M Vainio… - Acta …, 2017 - Wiley Online Library
Aim We studied whether available oxygen without induced mechanical stretch regulates the
release of the biologically active B-type natriuretic peptide (BNP) from Langendorff heart.
Methods Rat hearts were isolated and perfused with a physiological Krebs–Henseleit


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Expression and actions of corticotropin-releasing factor/diuretic hormone-like peptide (CDLP) and teneurin C-terminal associated peptide (TCAP) in the vase tunicate …

Expression and actions of corticotropin-releasing factor/diuretic hormone-like peptide (CDLP) and teneurin C-terminal associated peptide (TCAP) in the vase tunicate …

LD Andrea, AHR Hsieh, AHM Hsieh… - General and …, 2017 - Elsevier
Abstract Teneurin C-terminal associated peptide (TCAP) is a neuropeptide that bears some
structural similarity to the corticotropin-releasing factor (CRF) family of peptides. TCAP and
CRF are both implicated in the regulation of stress-related behaviors, as established in


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Ligand discovery for a peptide-binding GPCR by structure-based screening of fragment-and lead-like chemical libraries

Ligand discovery for a peptide-binding GPCR by structure-based screening of fragment-and lead-like chemical libraries

A Ranganathan, P Heine, A Rudling… - ACS chemical …, 2017 - ACS Publications
Peptide-recognizing G protein-coupled receptors (GPCRs) are promising therapeutic targets
but often resist drug discovery efforts. Determination of crystal structures for peptide-binding
GPCRs has provided opportunities to explore structure-based methods in lead


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Affinity capillary electrophoresis and density functional theory study of noncovalent interactions of cyclic peptide [Gly6]‐antamanide with small cations

Affinity capillary electrophoresis and density functional theory study of noncovalent interactions of cyclic peptide [Gly6]‐antamanide with small cations

S Pangavhane, S Böhm, E Makrlík, P Ruzza… - …, 2017 - Wiley Online Library
Abstract ACE and density functional theory (DFT) were employed to study the noncovalent
interactions of cyclic decapeptide glycine-6-antamanide ([Gly 6] AA), synthetic derivative of
native antamanide peptide from the deadly poisonous fungus Amanita phaloides, with small


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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