Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo
EK Sully, BL Geller, L Li, CM Moody… - Journal of …, 2017 - academic.oup.com
Objectives: The objective of this study was to test the efficacy of an inhibitor of the New Delhi
metallo-β-lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene
has the potential to restore antibiotic susceptibility in all bacteria carrying the gene. Methods:
metallo-β-lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene
has the potential to restore antibiotic susceptibility in all bacteria carrying the gene. Methods:
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