Exploration of the Innate Immune System of Styela clava: Zn2+ Binding Enhances the Antimicrobial Activity of the Tunicate Peptide Clavanin A
SA Juliano, S Pierce, JA DeMayo, MJ Balunas… - Biochemistry, 2017 - ACS Publications
Tunicates have been used as primitive models for understanding cell-mediated and humoral
immunity. Clavanin A (ClavA) is one member of a family of antimicrobial peptides produced
by the solitary tunicate Styela clava. In this work, we demonstrate that ClavA utilizes Zn2+
immunity. Clavanin A (ClavA) is one member of a family of antimicrobial peptides produced
by the solitary tunicate Styela clava. In this work, we demonstrate that ClavA utilizes Zn2+
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