Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology

Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology

E Obert, R Strauss, C Brandon, C Grek… - Journal of Molecular …, 2017 - Springer

Abstract A critical target tissue in age-related macular degeneration (AMD) is the retinal
pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier
dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula 

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