Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1‐34) Peptide Fragment
J Guo, A Khatri, A Maeda, JT Potts… - Journal of Bone and …, 2017 - Wiley Online Library
ABSTRACT Polyethylene glycol (PEG) addition can prolong the pharmacokinetic and
pharmacodynamic actions of a bioactive peptide in vivo, in part by impeding rates of
glomerular filtration. For parathyroid hormone (PTH) peptides, pegylation could help in
pharmacodynamic actions of a bioactive peptide in vivo, in part by impeding rates of
glomerular filtration. For parathyroid hormone (PTH) peptides, pegylation could help in
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