Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells

Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells

T Klonisch, A Glogowska… - British journal of …, 2017 - Wiley Online Library

Abstract We established the role of the GPCR relaxin/insulin-like family peptide receptor 1
(RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain
tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1

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