Creating an artificial tail anchor as a novel strategy to enhance the potency of peptide-based HIV fusion inhibitors

Creating an artificial tail anchor as a novel strategy to enhance the potency of peptide-based HIV fusion inhibitors

S Su, Y Zhu, S Ye, Q Qi, S Xia, Z Ma, F Yu… - Journal of …, 2017 - Am Soc Microbiol

ABSTRACT 20 (enfuvirtide) and other peptides derived from the human immunodeficiency
virus type 1 (HIV-1) gp41 C-terminal heptad repeat (CHR) region inhibit HIV fusion by
binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and 

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