Ligand discovery for a peptide-binding GPCR by structure-based screening of fragment-and lead-like chemical libraries
A Ranganathan, P Heine, A Rudling… - ACS chemical …, 2017 - ACS Publications
Peptide-recognizing G protein-coupled receptors (GPCRs) are promising therapeutic targets
but often resist drug discovery efforts. Determination of crystal structures for peptide-binding
GPCRs has provided opportunities to explore structure-based methods in lead
but often resist drug discovery efforts. Determination of crystal structures for peptide-binding
GPCRs has provided opportunities to explore structure-based methods in lead
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