2018年2月28日星期三

Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens

Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens

B Bufe, T Schumann, R Kappl, I Bogeski… - Journal of Biological …, 2015 - ASBMB
Results: We report the identification of bacterial signal peptides as potent activators of
mammalian FPRs and innate immune responses and define critical features underlying FPR
peptide recognition. Conclusion: These findings identify a molecular signature for FPR


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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Phytosulfokine peptide signalling

Phytosulfokine peptide signalling

M Sauter - Journal of Experimental Botany, 2015 - academic.oup.com
Abstract Phytosulfokine (PSK) belongs to the group of plant peptide growth factors. It is a
disulfated pentapeptide encoded by precursor genes that are ubiquitously present in higher
plants, suggestive of universal functions. Processing of the preproprotein involves


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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A7RC peptide modified paclitaxel liposomes dually target breast cancer

A7RC peptide modified paclitaxel liposomes dually target breast cancer

J Cao, R Wang, N Gao, M Li, X Tian, W Yang… - Biomaterials …, 2015 - pubs.rsc.org
A7R peptide (ATWLPPR), a ligand of the NRP-1 receptor, regulates the intracellular signal
transduction related to tumor vascularization and tumor growth. Here, we designed A7R-
cysteine peptide (A7RC) surface modified paclitaxel liposomes (A7RC-LIPs) to achieve


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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[HTML] A composite scaffold of MSC affinity peptide-modified demineralized bone matrix particles and chitosan hydrogel for cartilage regeneration

[HTML] A composite scaffold of MSC affinity peptide-modified demineralized bone matrix particles and chitosan hydrogel for cartilage regeneration

Q Meng, Z Man, L Dai, H Huang, X Zhang, X Hu… - Scientific reports, 2015 - nature.com
Abstract Articular cartilage injury is still a significant challenge because of the poor intrinsic
healing potential of cartilage. Stem cell-based tissue engineering is a promising technique
for cartilage repair. As cartilage defects are usually irregular in clinical settings, scaffolds


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Peptide-based in vivo siRNA delivery system

Peptide-based in vivo siRNA delivery system

DB Rozema, DL Lewis, D Wakefield, E Kitas… - US Patent …, 2015 - Google Patents
The present invention is directed compositions for targeted delivery of RNA interference
(RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are
administered together with co-targeted melittin delivery peptides. Delivery peptides provide

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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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[HTML] Scolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism

[HTML] Scolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism

H Lee, JS Hwang, J Lee, JI Kim, DG Lee - Biochimica et Biophysica Acta …, 2015 - Elsevier
Abstract Scolopendin 2 is a 16-mer peptide (AGLQFPVGRIGRLLRK) derived from the
centipede Scolopendra subspinipes mutilans. We observed that this peptide exhibited
antimicrobial activity in a salt-dependent manner against various fungal and bacterial


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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The powerful functions of peptide-based bioactive matrices for regenerative medicine

The powerful functions of peptide-based bioactive matrices for regenerative medicine

CMR Pérez, N Stephanopoulos, S Sur, SS Lee… - Annals of biomedical …, 2015 - Springer
Abstract In an effort to develop bioactive matrices for regenerative medicine, peptides have
been used widely to promote interactions with cells and elicit desired behaviors in vivo. This
paper describes strategies that utilize peptide-based molecules as building blocks to create


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Catalytic chemical amide synthesis at room temperature: One more step toward peptide synthesis

Catalytic chemical amide synthesis at room temperature: One more step toward peptide synthesis

T Mohy El Dine, W Erb, Y Berhault… - The Journal of …, 2015 - ACS Publications
An efficient method has been developed for direct amide bond synthesis between carboxylic
acids and amines via (2-(thiophen-2-ylmethyl) phenyl) boronic acid as a highly active bench-
stable catalyst. This catalyst was found to be very effective at room temperature for a large


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis

Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis

M Li, Z Tang, Y Zhang, S Lv, Q Li, X Chen - Acta biomaterialia, 2015 - Elsevier
Abstract The metastasis of breast cancer is the leading cause of cancer death in women. In
this work, an attempt to simultaneously inhibit the primary tumor growth and organ-specific
metastasis by the cisplatin-loaded LHRH-modified dextran nanoparticles (Dex-SA-CDDP-


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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What makes a good graphene-binding peptide? Adsorption of amino acids and peptides at aqueous graphene interfaces

What makes a good graphene-binding peptide? Adsorption of amino acids and peptides at aqueous graphene interfaces

ZE Hughes, TR Walsh - Journal of Materials Chemistry B, 2015 - pubs.rsc.org
Investigation of the non-covalent interaction of biomolecules with aqueous graphene
interfaces is a rapidly expanding area. However, reliable exploitation of these interfaces in
many applications requires that the links between the sequence and binding of the


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains

Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains

J Ebner, AA Arslan, M Fedorova, R Hoffmann… - Journal of …, 2015 - Elsevier
Abstract Kefir has a long tradition in human nutrition due to its presupposed health
promoting effects. To investigate the potential contribution of bioactive peptides to the
physiological effects of kefir, comprehensive analysis of the peptide profile was performed


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Biocatalytic Feedback‐Driven Temporal Programming of Self‐Regulating Peptide Hydrogels

Biocatalytic Feedback‐Driven Temporal Programming of Self‐Regulating Peptide Hydrogels

T Heuser, E Weyandt, A Walther - … Chemie International Edition, 2015 - Wiley Online Library
Abstract Switchable self-assemblies respond to external stimuli with a transition between
near-equilibrium states. Although being a key to present-day advanced materials, these
systems respond rather passively, and do not display autonomous dynamics. For


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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