Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC–MS analysis
MC Janin-Bussat, M Dillenbourg, N Corvaia… - … of Chromatography B, 2015 - Elsevier
Abstract Antibody-drug conjugates (ADCs) are becoming a major class of oncology
therapeutics. Because ADCs combine the monoclonal antibody specificity with the high
toxicity of a drug, they can selectively kill tumor cells while minimizing toxicity to normal cells.
therapeutics. Because ADCs combine the monoclonal antibody specificity with the high
toxicity of a drug, they can selectively kill tumor cells while minimizing toxicity to normal cells.
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