The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo
W Gao, JY Kim, JR Anderson, T Akopian… - Antimicrobial agents …, 2015 - Am Soc Microbiol
ABSTRACT Drug-resistant tuberculosis (TB) has lent urgency to finding new drug leads with
novel modes of action. A high-throughput screening campaign of> 65,000 actinomycete
extracts for inhibition of Mycobacterium tuberculosis viability identified ecumicin, a
novel modes of action. A high-throughput screening campaign of> 65,000 actinomycete
extracts for inhibition of Mycobacterium tuberculosis viability identified ecumicin, a
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