Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs

Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs

J Wang, V Yadav, AL Smart, S Tajiri… - Molecular …, 2015 - ACS Publications

A major barrier to successful oral delivery of peptide and protein molecules is their inherent
instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the
stability of 17 disparate peptide drugs (insulin, calcitonin, glucagon, secretin, somatostatin,

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