2018年5月3日星期四

De novo design and engineering of non-ribosomal peptide synthetases

De novo design and engineering of non-ribosomal peptide synthetases

KAJ Bozhüyük, F Fleischhacker, A Linck, F Wesche… - Nature …, 2018 - nature.com
Peptides derived from non-ribosomal peptide synthetases (NRPSs) represent an important
class of pharmaceutically relevant drugs. Methods to generate novel non-ribosomal
peptides or to modify peptide natural products in an easy and predictable way are therefore …


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