Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency
MC Lu, Q Jiao, T Liu, SJ Tan, HS Zhou, QD You… - European journal of …, 2018 - Elsevier
Abstract Directly disrupting Keap1-Nrf2 protein-protein interaction (PPI) has emerged as a
novel way to activate Nrf2. Peptide Keap1-Nrf2 PPI inhibitors have been reported with high
Keap1 binding affinity. However, these peptide inhibitors show weak activity in cells. In this …
novel way to activate Nrf2. Peptide Keap1-Nrf2 PPI inhibitors have been reported with high
Keap1 binding affinity. However, these peptide inhibitors show weak activity in cells. In this …
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