2018年5月21日星期一

Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity

Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity

M Takeuchi, M Okamoto, R Okamoto, H Kinoshita… - Peptides, 2018 - Elsevier
In the course of our search for new GLP-1 analogs, we screened a number of [Ser 8]-GLP-1
analogs using the C-terminal helix 3 of the albumin binding domain 3 of protein G from
bacterial Streptococcal G strain 148 (G148-ABD3) as appendage. Our efforts led to the …


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