2018年7月31日星期二

[HTML] Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral …

[HTML] Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral …

MU Mirza, S Rafique, A Ali, M Munir, N Ikram… - Scientific reports, 2016 - nature.com
The recent outbreak of Zika virus (ZIKV) infection in Brazil has developed to a global health
concern due to its likely association with birth defects (primary microcephaly) and
neurological complications. Consequently, there is an urgent need to develop a vaccine to …


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*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

PM Perin, S Haid, RJP Brown, J Doerrbecker… - …, 2016 - Wiley Online Library
To explore mechanisms of hepatitis C viral (HCV) replication we screened a compound
library including licensed drugs. Flunarizine, a diphenylmethylpiperazine used to treat
migraine, inhibited HCV cell entry in vitro and in vivo in a genotype‐dependent fashion …


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly

Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly

L Adler-Abramovich, P Marco, ZA Arnon… - ACS …, 2016 - ACS Publications
Molecular self-assembly of peptides into ordered nanotubes is highly important for various
technological applications. Very short peptide building blocks, as short as dipeptides, can
form assemblies with unique mechanical, optical, piezoelectric, and semiconductive …


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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A dual thermal and photo-switchable shrinking–swelling supramolecular peptide dendron gel

A dual thermal and photo-switchable shrinking–swelling supramolecular peptide dendron gel

F Xie, L Qin, M Liu - Chemical Communications, 2016 - pubs.rsc.org
A supramolecular dendron gel was fabricated through the co-assembly of an L-glutamic acid
terminated amphiphilic dendron and a positively charged azobenzene derivative, which
showed a dual thermal and photo-switched reversible volume phase transition or …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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New development in studies of formyl‐peptide receptors: critical roles in host defense

New development in studies of formyl‐peptide receptors: critical roles in host defense

L Li, K Chen, Y Xiang, T Yoshimura… - Journal of leukocyte …, 2016 - Wiley Online Library
Formyl-peptide receptors are a family of 7 transmembrane domain, Gi-protein-coupled
receptors that possess multiple functions in many pathophysiologic processes because of
their expression in a variety of cell types and their capacity to interact with a variety of …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Antioxidant activity of fermented meat sauce and isolation of an associated antioxidant peptide

Antioxidant activity of fermented meat sauce and isolation of an associated antioxidant peptide

M Ohata, S Uchida, L Zhou, K Arihara - Food Chemistry, 2016 - Elsevier
The present study was carried out to investigate the radical scavenging and antioxidant
activities of fermented meat sauce (FMS) against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and
the hydroxyl radical (OH-radical), as well as to isolate substances in FMS related to its …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Lipid-based nanoformulations for peptide delivery

Lipid-based nanoformulations for peptide delivery

N Matougui, L Boge, AC Groo, A Umerska… - International journal of …, 2016 - Elsevier
Nanoformulations have attracted a lot of attention because of their size-dependent
properties. Among the array of nanoformulations, lipid nanoformulations (LNFs) have
evoked increasing interest because of the advantages of their high degree of …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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LC–QTOF-MS identification of porcine-specific peptide in heat treated pork identifies candidate markers for meat species determination

LC–QTOF-MS identification of porcine-specific peptide in heat treated pork identifies candidate markers for meat species determination

SA Sarah, WN Faradalila, MS Salwani, I Amin… - Food chemistry, 2016 - Elsevier
The purpose of this study was to identify porcine-specific peptide markers from thermally
processed meat that could differentiate pork from beef, chevon and chicken meat. In the
initial stage, markers from tryptic digested protein of chilled, boiled and autoclaved pork …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
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*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Resistance of Cu(Aβ4–16) to Copper Capture by Metallothionein‐3 Supports a Function for the Aβ4–42 Peptide as a Synaptic CuII Scavenger

Resistance of Cu(Aβ4–16) to Copper Capture by Metallothionein‐3 Supports a Function for the Aβ4–42 Peptide as a Synaptic CuII Scavenger

NE Wezynfeld, E Stefaniak, K Stachucy… - Angewandte Chemie …, 2016 - Wiley Online Library
Aβ4‐42 is a major species of Aβ peptide in the brains of both healthy individuals and those
affected by Alzheimer's disease. It has recently been demonstrated to bind CuII with an
affinity approximately 3000 times higher than the commonly studied Aβ1‐42 and Aβ1‐40 …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Calcitonin and amylin receptor peptide interaction mechanisms: insights into peptide-binding modes and allosteric modulation of the calcitonin receptor by receptor …

Calcitonin and amylin receptor peptide interaction mechanisms: insights into peptide-binding modes and allosteric modulation of the calcitonin receptor by receptor …

SM Lee, DL Hay, AA Pioszak - Journal of biological chemistry, 2016 - ASBMB
Receptor activity-modifying proteins (RAMP1-3) determine the selectivity of the class B
GPCRs calcitonin receptor (CTR) and the CTR-like receptor (CLR), for calcitonin (CT),
amylin (Amy), CGRP, and adrenomedullin (AM) peptides. RAMP1/2 alter CLR selectivity for …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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[HTML] Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

[HTML] Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

I Metz, T Beißbarth, D Ellenberger, F Pache… - Neurology …, 2016 - AAN Enterprises
Objective: To assess in an observational study whether serum peptide antibody reactivities
may distinguish aquaporin-4 (AQP4) antibody (Ab)–positive and-negative neuromyelitis
optica spectrum disorders (NMOSD) and relapsing-remitting multiple sclerosis (RRMS) …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec)

Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec)

S Zhu, S Chen, Y Gao, F Guo, F Li, B Xie, J Zhou… - Drug …, 2016 - Taylor & Francis
Biodegradable polymer nanoparticle drug carriers are an attractive strategy for oral delivery
of peptide and protein drugs. However, their ability to cross the intestinal epithelium
membrane is largely limited. Therefore, in the present study, cell-penetrating peptides (R8 …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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