2018年7月27日星期五

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

SJ de Veer, CK Wang, JM HarrisDJ Craik… - Journal of medicinal …, 2015 - ACS Publications
Standard mechanism inhibitors are attractive design templates for engineering reversible
serine protease inhibitors. When optimizing interactions between the inhibitor and target
protease, many studies focus on the nonprimed segment of the inhibitor's binding loop …


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