An In‐tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide
The addition of a precisely positioned chiral center in the tether of a constrained peptide is
reported, yielding two separable peptide diastereomers with significantly different helicity, as
supported by circular dichroism (CD) and NMR spectroscopy. Single crystal X‐ray diffraction …
reported, yielding two separable peptide diastereomers with significantly different helicity, as
supported by circular dichroism (CD) and NMR spectroscopy. Single crystal X‐ray diffraction …
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