Resistance of Cu(Aβ4–16) to Copper Capture by Metallothionein‐3 Supports a Function for the Aβ4–42 Peptide as a Synaptic CuII Scavenger

Resistance of Cu(Aβ4–16) to Copper Capture by Metallothionein‐3 Supports a Function for the Aβ4–42 Peptide as a Synaptic Cu^II Scavenger

NE Wezynfeld, E Stefaniak, K Stachucy… - Angewandte Chemie …, 2016 - Wiley Online Library

Aβ4‐42 is a major species of Aβ peptide in the brains of both healthy individuals and those
affected by Alzheimer's disease. It has recently been demonstrated to bind CuII with an
affinity approximately 3000 times higher than the commonly studied Aβ1‐42 and Aβ1‐40 …

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