Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

PM Perin, S Haid, RJP Brown, J Doerrbecker… - …, 2016 - Wiley Online Library

To explore mechanisms of hepatitis C viral (HCV) replication we screened a compound
library including licensed drugs. Flunarizine, a diphenylmethylpiperazine used to treat
migraine, inhibited HCV cell entry in vitro and in vivo in a genotype‐dependent fashion …

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