Attenuation of Murine Airway Contraction Ex Vivo and In Vivo by a Gelsolin Peptide Containing the Phosphatidylinositol 4, 5-Bisphosphate Binding Domain

Attenuation of Murine Airway Contraction Ex Vivo and In Vivo by a Gelsolin Peptide Containing the Phosphatidylinositol 4, 5-Bisphosphate Binding Domain

M Mikami, J Perez-Zoghbi, CW Emala - A29. NOVEL MECHANISMS …, 2018 - atsjournals.org

RATIONALE: Gelsolin is an actin severing and capping protein that contains a binding
domain for phosphatidylinositol 4, 5-bisphosphate (PIP2). PIP2 is the substrate for
phospholipase Cβ (PLCβ) synthesis of inositol triphosphate (IP3), a critical regulator of …

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