[PDF] A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

[PDF] A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

A Saponaro, F Cantini, A Porro, A Bucchi… - eLife, 2018 - cdn.elifesciences.org

Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian
hyperpolarization-activated cyclic nucleotide-gated (HCN) channels prevents their
regulation by cAMP. Since TRIP8b is expressed exclusively in the brain, we envisage that it …

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