262. Therapeutic Suppression of the KRAS-MYC Oncogenic Axis in Human Pancreatic Cancer Xenografts with U1 Adaptor Oligonucleotide/RGD Peptide Conjugates

262. Therapeutic Suppression of the KRAS-MYC Oncogenic Axis in Human Pancreatic Cancer Xenografts with U1 Adaptor Oligonucleotide/RGD Peptide Conjugates

D Carpizo, A Tsang, X Yu, L Yi, C Dudgeon… - Molecular Therapy, 2016 - cell.com

U1 Adaptors are synthetic oligonucleotides that enable the U1 small nuclear
ribonucleoprotein (U1 snRNP) complex to stably bind within the terminal exon of a specific
pre-mRNA. This interferes with the obligatory polyadenylation step in mRNA maturation …

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