Caspase-2 Antibody

Product	Caspase-2 Antibody
Cat#	100-2-47A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H, M
Tested Application(s)	E, WB, ICC
Brief Description	(NT) a caspase induced by ER stress and DNA damage
Specific Description	Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).
Storage	Caspase-2 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.