[HTML] Antimicrobial peptide LL37 and MAVS signaling drive interferon-β production by epidermal keratinocytes during skin injury

[HTML] Antimicrobial peptide LL37 and MAVS signaling drive interferon-β production by epidermal keratinocytes during skin injury

L Zhang, GL Sen, NL Ward, A Johnston, K Chun… - Immunity, 2016 - Elsevier

Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible
for inducing these cytokines are not well understood. We found that IFN-β was abundantly
produced by epidermal keratinocytes (KCs) in psoriasis and during wound repair. KC IFN-β …

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