[HTML] Bystander activity and in vivo efficacy of a folate receptor α (FRα)-targeting antibody-drug conjugate with a novel peptide linker

[HTML] Bystander activity and in vivo efficacy of a folate receptor α (FRα)-targeting antibody-drug conjugate with a novel peptide linker

Q Qiu, R Wu, L Lanieri, E Maloney, A Skaletskaya… - 2017 - AACR

Folate receptor α (FRα) is an antigen that is overexpressed on the cell surface of solid
tumors including ovarian cancer. The differential expression on cancer cells makes FRα an
attractive target for antibody-drug conjugates (ADCs), and an ADC targeting FRα …

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