2017年12月22日星期五

A highly selective and sensitive LC–MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers

A highly selective and sensitive LC–MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers

R Ramanathan, AJ King-Ahmad, CL Holliman… - Bioanalysis, 2017 - Future Science
Aim: Coproporphyrin-I (CP-I) and coproporphyrin-III (CP-III) in plasma and urine have been
proposed as biomarkers for assessing drug–drug interactions involving hepatic drug
transporters such as organic anion-transporting peptides (OATP), 1B1 and 1B3. Materials & 


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