Chemical Protein Synthesis Using a Second-Generation N-Acylurea Linker for the Preparation of Peptide-Thioester Precursors
JB Blanco-Canosa, B Nardone, F Albericio… - Journal of the …, 2015 - ACS Publications
The broad utility of native chemical ligation (NCL) in protein synthesis has fostered a search
for methods that enable the efficient synthesis of C-terminal peptide-thioesters, key
intermediates in NCL. We have developed an N-acylurea (Nbz) approach for the synthesis
for methods that enable the efficient synthesis of C-terminal peptide-thioesters, key
intermediates in NCL. We have developed an N-acylurea (Nbz) approach for the synthesis
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