Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

DK Das, Y Feng, RJ Mallis, X Li… - Proceedings of the …, 2015 - National Acad Sciences

Abstract The αβ T-cell receptor (TCR) on each T lymphocyte mediates exquisite specificity
for a particular foreign peptide bound to a major histocompatibility complex molecule
(pMHC) displayed on the surface of altered cells. This recognition stimulates protection in

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