2018年3月28日星期三

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

R Kong, K Xu, T Zhou, P Acharya, T Lemmin… - …, 2016 - science.sciencemag.org
The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the
Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report
the identification of a neutralizing antibody, N123-VRC34. 01, which targets the fusion …


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A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

R Zhang, JJ Miner, MJ Gorman, K Rausch, H Ramage… - Nature, 2016 - nature.com
Abstract Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy
is available 1, 2. We performed a genome-wide CRISPR/Cas9-based screen to identify host
genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
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Pepmic Co., Ltd
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Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

SJ Lam, NM O'Brien-Simpson, N Pantarat… - Nature …, 2016 - nature.com
Abstract With the recent emergence of reports on resistant Gram-negative 'superbugs',
infections caused by multidrug-resistant (MDR) Gram-negative bacteria have been named
as one of the most urgent global health threats due to the lack of effective and biocompatible …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
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*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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[HTML] New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products

[HTML] New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products

MA Ortega, WA Van Der Donk - Cell chemical biology, 2016 - Elsevier
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique
biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
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Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

EJ Drake, BR Miller, C Shi, JT Tarrasch, JA Sundlov… - Nature, 2016 - nature.com
Abstract Many important natural products are produced by multidomain non-ribosomal
peptide synthetases (NRPSs) 1, 2, 3, 4. During synthesis, intermediates are covalently
bound to integrated carrier domains and transported to neighbouring catalytic domains in an …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
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*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Peptide‐Modulated Self‐Assembly of Chromophores toward Biomimetic Light‐Harvesting Nanoarchitectonics

Peptide‐Modulated Self‐Assembly of Chromophores toward Biomimetic Light‐Harvesting Nanoarchitectonics

Q Zou, K Liu, M Abbas, X Yan - Advanced Materials, 2016 - Wiley Online Library
Abstract Elegant self-assembling complexes by the combination of proteins/peptides with
functional chromophores are decisively responsible for highly efficient light-harvesting and
energy transfer in natural photosynthetic systems. Mimicking natural light-harvesting …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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[HTML] The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones

[HTML] The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones

CL Meek, HB Lewis, F Reimann, FM Gribble, AJ Park - Peptides, 2016 - Elsevier
Abstract Bariatric surgery for obesity has proved to be an extremely effective method of
promoting long-term weight reduction with additional beneficial metabolic effects, such as
improved glucose tolerance and remission of type 2 diabetes. A range of bariatric …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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[HTML] Review of head‐to‐head comparisons of glucagon‐like peptide‐1 receptor agonists

[HTML] Review of head‐to‐head comparisons of glucagon‐like peptide‐1 receptor agonists

S Madsbad - Diabetes, Obesity and Metabolism, 2016 - Wiley Online Library
Abstract Currently, six glucagon-like peptide-1 receptor agonists (GLP-1RAs) are approved
for treating type 2 diabetes. These fall into two classes based on their receptor activation:
short-acting exenatide twice daily and lixisenatide once daily; and longer-acting liraglutide …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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Peptide self-assembly: thermodynamics and kinetics

Peptide self-assembly: thermodynamics and kinetics

J Wang, K Liu, R Xing, X Yan - Chemical Society Reviews, 2016 - pubs.rsc.org
Self-assembling systems play a significant role in physiological functions and have therefore
attracted tremendous attention due to their great potential for applications in energy,
biomedicine and nanotechnology. Peptides, consisting of amino acids, are among the most …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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[HTML] Advances in Fmoc solid‐phase peptide synthesis

[HTML] Advances in Fmoc solid‐phase peptide synthesis

R Behrendt, P White, J Offer - Journal of Peptide Science, 2016 - Wiley Online Library
Abstract Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality
Fmoc building blocks are available at low cost because of the economies of scale arising
from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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[HTML] The cardiovascular biology of glucagon-like peptide-1

[HTML] The cardiovascular biology of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2016 - Elsevier
Glucagon-like peptide-1, produced predominantly in enteroendocrine cells, controls glucose
metabolism and energy homeostasis through regulation of islet hormone secretion,
gastrointestinal motility, and food intake, enabling development of GLP-1 receptor (GLP-1R) …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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2018年3月27日星期二

[HTML] Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

[HTML] Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

MJ Armstrong, D Hull, K Guo, D Barton… - Journal of …, 2016 - journal-of-hepatology.eu
Background & Aims Insulin resistance and lipotoxicity are pathognomonic in non-alcoholic
steatohepatitis (NASH). Glucagon-like peptide-1 (GLP-1) analogues are licensed for type 2
diabetes, but no prospective experimental data exists in NASH. This study determined the …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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