Structures of two distinct conformations of holo-non-ribosomal peptide synthetases
Abstract Many important natural products are produced by multidomain non-ribosomal
peptide synthetases (NRPSs) 1, 2, 3, 4. During synthesis, intermediates are covalently
bound to integrated carrier domains and transported to neighbouring catalytic domains in an …
peptide synthetases (NRPSs) 1, 2, 3, 4. During synthesis, intermediates are covalently
bound to integrated carrier domains and transported to neighbouring catalytic domains in an …
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