2018年3月26日星期一

De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II …

De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II …

J Dufour-Gallant, D Chatenet… - Journal of medicinal …, 2015 - ACS Publications
A proof-of-concept library of pyrrolodiazepinone small molecules was designed based on
the Bip-Lys-Tyr motif found in a recently described modulator of the urotensinergic system.
Solid-phase synthesis provided 13 analogues, which were tested for their ability to modulate …


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