Inhibition of β-Amyloid aggregation Through a Designed β-hairpin Peptide

Inhibition of β-Amyloid aggregation Through a Designed β-hairpin Peptide

A Jha, MG Kumar, HN Gopi, KM Paknikar - Langmuir, 2018 - ACS Publications

Designing peptide-based drugs to target the β-sheet-rich toxic intermediates during the
aggregation of amyloid-β 1-42 (Aβ1-42) has been a major challenge. In general, β-sheet
breaker peptides (BSBPs) are designed to complement the enthalpic interactions with the …

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