Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity
RD DiMarchi, B Yang, C Ouyang - US Patent 8,980,830, 2015 - Google Patents
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist
activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified
amino acid sequence of native glucagon, in which the first one to five N-terminal amino …
activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified
amino acid sequence of native glucagon, in which the first one to five N-terminal amino …
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