Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity
FF Hsu, CT Yeh, YJ Sun, MT Chiang, WM Lan, FA Li… - Oncogene, 2015 - nature.com
Abstract Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the
endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). HO-1 is
highly expressed in various cancers and its nuclear localization is associated with the …
endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). HO-1 is
highly expressed in various cancers and its nuclear localization is associated with the …
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