Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP
JC Deacon, DM Engelman, FN Barrera - Archives of biochemistry and …, 2015 - Elsevier
Abstract pHLIPs are a family of soluble∼ 36 amino acid peptides, which bind to membrane
surfaces. If the environment is acidic, a pHLIP folds and inserts across the membrane to form
a stable transmembrane helix, thus preferentially locating itself in acidic tissues. Since …
surfaces. If the environment is acidic, a pHLIP folds and inserts across the membrane to form
a stable transmembrane helix, thus preferentially locating itself in acidic tissues. Since …
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