Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation

Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation

E Fernández-Millán, MA Martín, L Goya… - Free Radical Biology …, 2016 - Elsevier

Oxidative stress plays an important role in the development of beta-cell dysfunction and
insulin resistance, two major pathophysiological abnormalities of type 2 diabetes.
Expression levels of antioxidant enzymes in beta cells are very low, rendering them more …

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