2018年12月13日星期四

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

MA Ali, YF Liu, S Arif, D Tatovic, H Shariff… - Science translational …, 2017 - stm.sciencemag.org
Immunotherapy using short immunogenic peptides of disease-related autoantigens restores
immune tolerance in preclinical disease models. We studied safety and mechanistic effects
of injecting human leukocyte antigen–DR4 (DRB1* 0401)–restricted immunodominant …


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