2018年2月1日星期四

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

DA Sanan, KH Weisgraber, SJ Russell… - The Journal of …, 1994 - Am Soc Clin Investig
Late-onset and sporadic Alzheimer's disease are associated with the apolipoprotein E
(apoE) type 4 allele expressing the protein isoform apoE4. Apolipoprotein E binds avidly to (8
amyloid (Afl) peptide, a major component of senile plaque of Alzheimer's disease, in an


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