Solution Structure of Amyloid β-Peptide(1−40) in a Water−Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is?,

Solution Structure of Amyloid β-Peptide(1−40) in a Water−Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is?^,

M Coles, W Bicknell, AA Watson, DP Fairlie… - Biochemistry, 1998 - ACS Publications

The three-dimensional solution structure of the 40 residue amyloid β-peptide, Aβ (1− 40),
has been determined using NMR spectroscopy at pH 5.1, in aqueous sodium dodecyl
sulfate (SDS) micelles. In this environment, which simulates to some extent a water−

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