A novel strategy through combining iRGD peptide with tumor-microenvironment-responsive and multistage nanoparticles for deep tumor penetration

A novel strategy through combining iRGD peptide with tumor-microenvironment-responsive and multistage nanoparticles for deep tumor penetration

X Cun, J Chen, S Ruan, L Zhang, J Wan… - … applied materials & …, 2015 - ACS Publications

Despite the great achievements that nanomedicines have obtained so far, deep penetration
of nanomedicines into tumors is still a major challenge in tumor treatment. The enhanced
permeability and retention (EPR) effect was the main theoretical foundation for using

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