Biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo
Z Tai, X Wang, J Tian, Y Gao, L Zhang, C Yao… - …, 2015 - ACS Publications
RNA-based delivery system for cancer therapy remains a challenge. In this study, a stearyl-
peptide (SHR) was synthesized using arginine, histidine, cysteine, and stearyl moieties.
Further, the stearyl-peptides were cross-linked by disulfide bonds to obtain cross-linked
peptide (SHR) was synthesized using arginine, histidine, cysteine, and stearyl moieties.
Further, the stearyl-peptides were cross-linked by disulfide bonds to obtain cross-linked
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