Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels
SH Medina, S Li, OMZ Howard, M Dunlap, A Trivett… - Biomaterials, 2015 - Elsevier
Abstract DNA that encodes tumor-specific antigens represents potential immunostimulatory
agents. However, rapid enzymatic degradation and fragmentation of DNA during
administration can result in limited vector expression and, consequently, poor efficacy.
agents. However, rapid enzymatic degradation and fragmentation of DNA during
administration can result in limited vector expression and, consequently, poor efficacy.
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