Histone H3 peptide based LSD1-selective inhibitors
T Kakizawa, Y Ota, Y Itoh, H Tsumoto… - Bioorganic & medicinal …, 2015 - Elsevier
Abstract A series of candidates for the histone H3 peptide based LSD1-selective inhibitor
were designed and synthesized. Among peptides 1a–c and 2a–c, peptide 1a, which has a
phenylcyclopropylamine (PCPA) moiety at Lys-4 of the 21 amino acid residues of histone
were designed and synthesized. Among peptides 1a–c and 2a–c, peptide 1a, which has a
phenylcyclopropylamine (PCPA) moiety at Lys-4 of the 21 amino acid residues of histone
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