[HTML] Development of highly selective Kv1. 3-blocking peptides based on the sea anemone peptide ShK

[HTML] Development of highly selective Kv1. 3-blocking peptides based on the sea anemone peptide ShK

MW Pennington, SC Chang, S Chauhan, R Huq… - Marine drugs, 2015 - mdpi.com

Abstract: ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich
peptide that blocks the voltage-gated potassium channel Kv1. 3 at ca. 10 pM and the related
channel Kv1. 1 at ca. 16 pM. We developed an analog of this peptide, ShK-186, which is

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