2018年3月10日星期六

[HTML] Structure and Mechanism of an Aspartimide‐Dependent Peptide Ligase in Human Legumain

[HTML] Structure and Mechanism of an Aspartimide‐Dependent Peptide Ligase in Human Legumain

E Dall, JC Fegg, P Briza… - Angewandte Chemie …, 2015 - Wiley Online Library
Abstract Peptide ligases expand the repertoire of genetically encoded protein architectures
by synthesizing new peptide bonds, energetically driven by ATP or NTPs. Here, we report
the discovery of a genuine ligase activity in human legumain (AEP) which has important


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