2018年3月8日星期四

[HTML] Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso peptide from an understudied halophilic actinomycete

[HTML] Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso peptide from an understudied halophilic actinomycete

M Metelev, JI Tietz, JO Melby, PM Blair, L Zhu, I Livnat… - Chemistry & biology, 2015 - Elsevier
Summary Natural products are the most historically significant source of compounds for drug
development. However, unacceptably high rates of compound rediscovery associated with
large-scale screening of common microbial producers have resulted in the abandonment of


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